Promethazine Promethazine is a phenothiazine derivative, which differs structurally from the antipsychotic phenothiazines with the existence of a branched aspect chain and no ring substitution.
e., various copies from the gene for cytochrome P450 isoenzyme 2D6 or superior morphine concentrations). Kids with slumber apnea may be especially sensitive on the respiratory depressant results of codeine.
Epinephrine – Because of the prospective for promethazine to reverse epinephrine's vasopressor effect, epinephrine really should not be utilised to treat hypotension linked to promethazine overdose.
Abuse and dependancy are independent and distinctive from Bodily dependence and tolerance. Well being treatment vendors ought to be conscious that addiction will not be accompanied by concurrent tolerance and indicators of physical dependence in all addicts. In addition, abuse of opioids can arise inside the absence of correct dependancy.
Physical dependence, the ailment wherein ongoing administration on the drug is necessary to stop the looks of the withdrawal syndrome, assumes clinically substantial proportions only after many months of continued oral opioid use, Though some moderate degree of Actual physical dependence might build soon after a couple of days of opioid therapy.
Parenteral drug abuse is usually connected with transmission of infectious health conditions including hepatitis and HIV.
The next severe adverse reactions are explained, or described in bigger depth, in other sections:
Shop at area temperature clear of light and humidity. Usually do not retailer in the toilet. Don't freeze. Keep all drugs faraway from youngsters and pets.
The combination of promethazine hydrochloride and codeine phosphate need to be utilised with warning in pediatric clients 6 a long time and more mature (see Warnings-Use in Pediatric Patients).
Drug interactions may possibly adjust how your remedies operate or boost your threat for severe side effects. This doc will not incorporate all doable drug interactions.
Instruct nursing moms to speak to the child's health practitioner promptly if they detect these symptoms and, if they can't get to the medical professional right away, to go ahead and take baby to an unexpected emergency room or get in touch with 911 (or local emergency solutions).
Tend not to flush medications down the bathroom or pour them right into a drain unless instructed to take action. Thoroughly discard this product or service when it's expired or no more required. Speak to your pharmacist or local squander disposal corporation.
This drug may perhaps make you dizzy or drowsy or blur your vision. Alcoholic beverages or marijuana (cannabis) might make you more dizzy or drowsy. Don't drive, use equipment, or do anything that needs alertness Promethazine codeine syrup or apparent eyesight right until you can do it properly.
DailyMed will deliver notification of updates and additions to Drug Label details at this time shown on This web site by its RSS feed.